Mindfulness based stress reduction (MBSR) has been demonstrated to have beneficial effects relative to several physiologic measurements in humans. These include improved immune status, decreased inflammation as measured by blood tests, improved DNA repair (increased telomere length), and alterations in metabolic activity in areas of the brain that are viewed as beneficial relative to stress, anxiety and pain as measured by functional MRI scan of the brain (fMRI). Similarly other forms of meditation have been studied relative to cardiovascular risk in humans. The results indicate that stress reduction from meditation can decrease the “composite risk of death, heart attack and stroke” by 48% in patients who have experienced a previous heart attack. (1)
“A selected mind-body intervention, the TM program, significantly reduced risk for mortality, myocardial infarction, and stroke in coronary heart disease patients. These changes were associated with lower blood pressure and psychosocial stress factors. Therefore, this practice may be clinically useful in the secondary prevention of cardiovascular disease.”
This degree of protection exceeds the benefits of statin drugs in patients who have had a heart attack and exceeds the risk reduction accomplished by cardiac rehabilitation exercise programs.
A review of studies on the effects of meditation on cardiovascular disease reported: (2)
Psychosocial stress is a nontraditional risk factor for cardiovascular morbidity and mortality that may respond to behavioral or psychosocial interventions. …. Randomized controlled trials, meta-analyses, and other controlled studies indicate this meditation technique reduces risk factors and can slow or reverse the progression of pathophysiological changes underlying cardiovascular disease. Studies with this technique have revealed reductions in blood pressure, carotid artery intima-media thickness, myocardial ischemia, left ventricular hypertrophy, mortality, and other relevant outcomes. The magnitudes of these effects compare favorably with those of conventional interventions for secondary prevention
Dr. Dean Ornish utilized both meditation and yoga training in his lifestyle intervention program along with moderate exercise, smoke cessation and elimination of junk food (low fat vegan diet). The results demonstrated reduced coronary artery plaque within 2 years. Although many have attributed this to the vegan low fat diet, I have suggested in the past that the beneficial results were accomplished by stress reduction, exercise, smoke cessation, and elimination of junk food (especially refined sugar, flour, trans-fats and refined vegetable oils)
Our culture is not attuned to the regular practice of meditation or yoga. When I recommend stress reduction with these techniques to my patients few pursue it despite providing them with detailed descriptions of the physical benefits demonstrated by medical studies. One does not need to become a Buddhist in order to benefit from the practice of meditation. In the early 1970s the first stress reduction clinic utilizing MBSR(Mindfulness Based Stress Reduction) and Yoga was established at the University of Massachusetts Medical Center by Jon Kabat Zinn PhD. Since then many studies have documented the benefits of stress reduction relative to cardiovascular disease, diabetes, hypertension, chronic pain management, depression and anxiety.
Patients who have experienced their first major depressive episode can reduce the risk of a subsequent major depressive episode by 50% simply practicing MBSR regularly.
Unlike drugs, angioplasty, coronary stents, surgery, and injections, meditation and yoga have no potential negative side effects or complications. They simply require time, practice and a modest amount of training. Inexpensive self-help books, CDs and on-line resources are available to get started. Measurable physiologic benefits are experienced within a few weeks. Blood pressure drops, stress hormones decrease, blood sugars come down, insulin sensitivity improves, immune cells work better, sleep improves, suffering from chronic pain decreases, and functional status improves. That’s a considerable amount of benefit achieved by simply sitting quietly and observing your breath as it moves in and out of your body.
Meditation and yoga are two ways to reduce stress. For a healthy life to achieve stress reduction we must examine many areas. What aspects of daily life can increase and decrease stress and our physiologic response to stress?
Important factors to consider include social isolation, physical and social contact with friends/family/pets, meaningful work, laughter and humor, time spent outdoors, exercise, proper sleep habits and exposure to natural rather than artificial light. These all play significant roles in governing our stress levels, physiologic response to stress and the attendant changes in health.
Social isolation is harmful while regular contact with family and friends is beneficial. Caring for a pet seems to reduce blood pressure and enhance longevity. Engaging in meaningful work for pay or as a volunteer is essential for health, longevity and happiness. Spending time outdoors regularly and cycling your daily activity with the sun (circadian rhythm normalization) are essential to health and stress reduction. Laughter and social interaction provide healing while rumination over problems causes illness. All of these aspects to healthy living deserve attention but if you are ill, overweight, suffer chronic pain, disability or substance abuse then meditation and yoga can have profoundly beneficial effects. When combined with a Paleolithic diet and adequate restorative sleep, stress reduction techniques provide a powerful healing pathway.
Below is a long list of links to articles related to stress reduction, meditation, and yoga in the areas of chronic pain, cardiovascular disease, cancer, pre-natal care, anxiety disorders, depression, insomnia, smoke cessation, burnout, immune function, inflammation, migraine, blood pressure control, traumatic brain injury and even psoriasis.
Read to your heart’s content.
Bob Hansen MD
Here is the long list of other references. I have tried to group them in categories. There is allot of overlap between categories so my classification is somewhat arbitrary.
Asthma
Yoga intervention for adults with mild-to-moderate asthma: a pilot study.
Cardiovascular Disease:
Usefulness of the transcendental meditation pro… [Am J Cardiol. 1996] – PubMed – NCBI
A randomised controlled trial of stress reduction for hypertension in older African Americans.
Is there a role for stress management in reducing hypertension in African Americans?
Yoga for the primary prevention of cardiovascular disease.
Randomized controlled trial of mindfulness-based stress reduction for prehypertension.
Trial of relaxation in reducing coronary risk: four year follow up.
When and why do heart attacks occur? Cardiovascular triggers and their potential role.
Emotional stressors trigger cardiovascular events.
How brain influences neuro-cardiovascular dysfunction.
CNS effects:
Short-term meditation training improves attention and self-regulation
Central and autonomic nervous system interaction is altered by short-term meditation
Neruoimaging and EEG
Neural mechanisms of mindfulness and meditation: Evidence from neuroimaging studies.
Short-term meditation induces white matter changes in the anterior cingulate
Mechanisms of white matter changes induced by meditation
Cancer:
Keeping the balance–an overview of mind-body therapies in pediatric oncology.
Meditation, melatonin and breast/prostate cancer: hypothesis and preliminary data.
Diabetes
Immune System:
Alterations in brain and immune function produced by mindfulness meditation.
Insomnia and Sleep Physiology.
Mind-body interventions for the treatment of insomnia: a review.
New insights into circadian aspects of health and disease.
Irritable Bowel
Pain:
The validation of an active control intervention for Mindfulness Based Stress Reduction (MBSR).
[Mindfulness-based therapeutic approaches: benefits for individuals suffering from pain].
Mindfulness starts with the body: somatos… [Front Hum Neurosci. 2013] – PubMed – NCBI
Differential effects on pain intensity and unpleasantness of two meditation practices.
Effectiveness of mindfulness meditation (Vipassana) in the management of chronic low back pain.
Mindfulness meditation in the control of severe headache.
The clinical use of mindfulness meditation for the self-regulation of chronic pain.
Psych, Depression, Anxiety, Burnout, Students
Mindfulness meditation practices as adjunctive treatments for psychiatric disorders.
Reducing psychological distress and obesity through Yoga practice
Yoga and social support reduce prenatal depression, anxiety and cortisol.
Meditation Programs for Psychological Stress and Well-Being [Internet].
Meditation programs for psychological stress and well-being: a systematic review and meta-analysis.
Tai chi training reduces self-report of inattention in healthy young adults.
Mindfulness for teachers: A pilot study to assess effects on stress, burnout and teaching efficacy.
Mindfulness-based cognitive therapy for generalized anxiety disorder.
Effectiveness of a meditation-based stress reduction program in the treatment of anxiety disorders.
Intensive meditation training improves perceptual discrimination and sustained attention.
Mindfulness-based stress reduction lowers psychological distress in medical students.
The effect of yoga on coping strategies among intensive care unit nurses.
Psychological and neural mechanisms of trait mindfulness in reducing depression vulnerability.
A narrative review of yoga and mindfulness as complementary therapies for addiction.
Yoga and massage therapy reduce prenatal depression and prematurity.
Mind-body interventions during pregnancy for preventing or treating women’s anxiety.
Misc. and General
Empirical explorations of mindfulness: conceptual and methodological conundrums.
Mindfulness meditation: do-it-yourself medicalization of every moment.
Becoming conscious: the science of mindfulness.
Cultivating mindfulness: effects on well-being.
Mind-body medicine. An introduction and review of the literature.
Tai chi chuan in medicine and health promotion.
Tai chi/yoga effects on anxiety, heartrate, EEG and math computations.
Mindfulness Research Update: 2008.
Hair Cortisol as a Biomarker of Stress in Mindfulness Training for Smokers.
Body Awareness: a phenomenological inquiry into the common ground of mind-body therapies.
Cortical dynamics as a therapeutic mechanism for touch healing.
Establishing key components of yoga interventions for musculoskeletal conditions: a Delphi survey.
Becoming conscious: the science of mindfulness.
Organ Transplant
Mindfulness meditation to reduce symptoms after organ transplant: a pilot study.
Post Traumatic Brain Injury
Psoriasis
Telemorase, DNA, Genes
Rapid changes in histone deacetylases and inflammatory gene expression in expert meditators.
Can meditation slow rate of cellular aging? Cognitive stress, mindfulness, and telomeres.
Intensive meditation training, immune cell telomerase activity, and psychological mediators.
Contemplative practice, chronic fatigue, and telomerase activity: a comment on Ho et al.